2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140776
    Azido-PEG2-C2-Boc 1271728-79-0
    Azido-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-C2-Boc
  • HY-W090623
    Tos-PEG2-OH 118591-58-5
    Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG2-OH
  • HY-140719
    Mal-PEG-mal (MW 2000) 98.40%
    Mal-PEG-mal (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG-mal (MW 2000)
  • HY-140487
    Cbz-NH-PEG2-C2-acid 1347750-76-8
    Cbz-NH-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cbz-NH-PEG2-C2-acid
  • HY-140879
    Boc-N-Amido-PEG4-propargyl 1219810-90-8 99.63%
    Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-N-Amido-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Boc-N-Amido-PEG4-propargyl
  • HY-W096098
    Biotin-PEG3-CH2COOH 1189560-96-0
    Biotin-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG3-CH2COOH
  • HY-133065
    m-PEG5-NHS ester 874208-94-3 98.0%
    m-PEG5-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG5-NHS ester
  • HY-35261
    Mal-PEG2-NH2 660843-22-1
    Mal-PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG2-NH2
  • HY-140284A
    DBCO-PEG6-amine TFA 99.42%
    DBCO-PEG6-amine TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG6-amine (TFA) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG6-amine TFA
  • HY-138381
    Br-PEG6-C2-NHBoc 2688072-13-9 98.0%
    Br-PEG6-C2-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Br-PEG6-C2-NHBoc
  • HY-117031
    m-PEG8-MS 1059588-19-0
    m-PEG8-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG8-MS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG8-MS
  • HY-138406
    Boc-NH-PEG8-C2-Br 2688072-12-8
    Boc-NH-PEG8-C2-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG8-C2-Br
  • HY-41922
    Propargyl-PEG2-CH2COOH 944561-46-0
    Propargyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG2-CH2COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-CH2COOH
  • HY-135925
    Cbz-NH-PEG1-CH2COOH 1260092-43-0 99.73%
    Cbz-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cbz-NH-PEG1-CH2COOH
  • HY-133299
    Br-PEG7-Br 177987-04-1 98.0%
    Br-PEG7-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Br-PEG7-Br
  • HY-133457
    Biotin-PEG2-C1-aldehyde 2408505-11-1
    Biotin-PEG2-C1-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG2-C1-aldehyde
  • HY-133304
    HO-PEG10-CH2COOH 2250056-53-0 98.0%
    HO-PEG10-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG10-CH2COOH
  • HY-133404
    Fmoc-aminooxy-PFP ester
    Fmoc-aminooxy-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-aminooxy-PFP ester
  • HY-133276
    m-PEG7-Br 104518-25-4
    m-PEG7-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG7-Br
  • HY-W111228
    Fmoc-9-Aminononanoic acid 212688-52-3
    Fmoc-9-aminononanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and and other conjugation applications. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
    Fmoc-9-Aminononanoic acid
PROTAC Linkers Isoform Comparison

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